HI-TOPK-032 新

参考资料仅供科学研究，不可用于个人用途。

货号：BCP35692CAS号：487020-03-1纯度：98%

规格	价格(CNY)	是否现货	购买咨询
10.00 mg	￥1200.00	In-stock	购买咨询
25.00 mg	￥2300.00	In-stock	购买咨询
50.00 mg	￥3800.00	In-stock	购买咨询

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CAS号	487020-03-1	货号	BCP35692
中文名	HI-TOPK-032
英文名	HI-TOPK-032
中文别名
英文别名	HI-TOPK032; HI-TOPK 032;
SMILES	C1=CC=C2C(=C1)N=C3C(=C4C=C(C=CN4C3=N2)NC(=O)C5=CC=CS5)C#N
化学名称
分子式	C20H11N5OS	分子量	369.4
纯度	98%	配送	惯例下常温包邮
产品描述	HI-TOPK-032 is a potent and selective TOPK inhibitor. In vitro, HI-TOPK-032 strongly suppressed TOPK kinase activity but had little effect on extracellular signal–regulated kinase 1 (ERK1), c-jun—NH2—kinase 1, or p38 kinase activities. HI-TOPK-032 also inhibited anchorage-dependent and -independent colon cancer cell growth by reducing ERK-RSK phosphorylation as well as increasing colon cancer cell apoptosis through regulation of the abundance of p53, cleaved caspase-7, and cleaved PARP. In vivo, administration of HI-TOPK-032 suppressed tumor growth in a colon cancer xenograft model. HI-TOPK-032 may be further developed as a potential therapeutic against colorectal cancer. The serine-threonine mitogen-activated protein kinase kinase family member T-LAK cell–originated protein kinase (TOPK/PBK) is heavily involved in tumor development, cancer growth, apoptosis, and inflammation ( Cancer Res; 72(12); 3060–8.).