甲磺酸加贝酯

参考资料仅供科学研究，不可用于个人用途。

货号：BCP13557CAS号：56974-61-9纯度：98%

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CAS号	56974-61-9	货号	BCP13557
中文名	甲磺酸加贝酯
英文名	Gabexate mesylate
中文别名
英文别名	FOY;Gabexate Mesilate;
SMILES
化学名称
分子式	C17H27N3O7S	分子量	417.48
纯度	98%	配送	惯例下常温包邮
产品描述	Gabexate mesylate is a non-antigenic synthetic inhibitor of trypsin-like serine proteinases that is therapeutically used in the treatment of pancreatitis and disseminated intravascular coagulation and as a regional anticoagulant for hemodialysis. Values of the inhibition constant (K(i)) for gabexate mesylate binding to human and bovine tryptase were 3.4 x 10(-9) M and 1.8 x 10(-7) M (at pH 7.4 and 37.0 degrees ), respectively. Gabexate mesylate inhibited the fibrinogenolytic activity of human tryptase. Gabexate Mesylate decreased the TNFalpha production of LPS-stimulated monocytes as shown by the inhibition of mRNA expression and increased the IL-10 production of LPS-stimulated monocytes. Gabexate Mesylate also suppressed the NFkappaB activity of LPS-stimulated monocytes. Inhibitory effect of Gabexate Mesylate on the TNFalpha production of activated human monocytes is mediated by the suppression of NFkappaB activation . Gabexate mesylate inhibits competitively constitutive and inducibl