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| CAS号 | 702675-74-9 | 货号 | BCP01899 |
| 中文名 | BX795 | ||
| 英文名 | BX795 | ||
| 中文别名 | |||
| 英文别名 | BX 795;BX-795; | ||
| SMILES | |||
| 化学名称 | |||
| 分子式 | C23H26IN7O2S | 分子量 | 591.48 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | BX-795 effectively blocks PDK1 activity in PC-3 cells, as shown by their ability to block phosphorylation of S6K1, Akt, PKCδ, and GSK3β. BX-795 potently inhibits tumor cell growth on plastic with IC50 of 1.6, 1.4, and 1.9 μM for MDA-468, HCT-116 and MiaPaca cells, respectively. In soft agar, BX-795 displays higher growth inhibition with IC50 of 0.72, and 0.25 μM for MDA-468, and PC-3 cells, respectively. In addition, BX-795, as an inhibitor of the TBK1/IKK?, blocks TBK1- and IKKε-mediated activation of IRF3 and production of IFN-β. In platelet physiological responses, BX795 produces inhibitory effect on 2-MeSADP-induced or collagen-induced aggregation, ATP secretion and thromboxane generation. | ||
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