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| CAS号 | 859209-74-8 | 货号 | BCP38570 |
| 中文名 | GS-9219 | ||
| 英文名 | GS-9219 | ||
| 中文别名 | |||
| 英文别名 | GS 9219; GS9219;Rabacfosadine; | ||
| SMILES | CCOC(=O)C(C)NP(=O)(COCCN1C=NC2=C(N=C(N=C21)N)NC3CC3)NC(C)C(=O)OCC | ||
| 化学名称 | |||
| 分子式 | C21H35N8O6P | 分子量 | 526.53 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | GS-9219 is a prodrug of the acyclic nucleoside phosphonate analogue 9-(2-phosphonylmethoxyethyl)guanine (PMEG) with potential antineoplastic activity. Formulated to selectively accumulate in lymphocytes, nucleotide analogue GS 9219 is converted to its active metabolite, PMEG diphosphate (PMEGpp), via enzymatic hydrolysis, deamination, and phosphorylation; subsequently, PMEGpp is incorporated into nascent DNA chains by DNA polymerases, which may result in the termination of DNA synthesis, S-phase cell cycle arrest, and the induction of apoptosis in susceptible lymphoma cell populations. | ||
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