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| CAS号 | 905579-51-3 | 货号 | BCP01927 |
| 中文名 | MLN4924 | ||
| 英文名 | MLN4924 | ||
| 中文别名 | |||
| 英文别名 | TAK-924; TAK 924; TAK924;MLN-4924;MLN 4924; Pevonedistat; | ||
| SMILES | O=S(OC[C@@H]1C[C@@H](N2C3=NC=NC(N[C@]4CCC5=C4C=CC=C5)=C3C=C2)C[C@@H]1O)(N)=O | ||
| 化学名称 | |||
| 分子式 | C21H25N5O4S | 分子量 | 443.52 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | Pevonedistat, also known as MLN-4924 and TAK-924, is a small molecule inhibitor of Nedd8 activating enzyme (NAE) with potential antineoplastic activity. NAE inhibitor MLN4924 binds to and inhibits NAE, which may result in the inhibition of tumor cell proliferation and survival. NAE activates Nedd8 (Neural precursor cell expressed, developmentally down-regulated 8), an ubiquitin-like (UBL) protein that modifies cellular targets in a pathway that is parallel to but distinct from the ubiquitin-proteasome pathway (UPP). | ||
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