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| CAS号 | 911637-19-9 | 货号 | BCP40330 |
| 中文名 | 吉格列汀 | ||
| 英文名 | Gemigliptin | ||
| 中文别名 | |||
| 英文别名 | LC15-0444; LC150444; LC-150444; LC 150444; | ||
| SMILES | C1CC(CN(C1=O)CC(CC(=O)N2CCC3=C(C2)N=C(N=C3C(F)(F)F)C(F)(F)F)N)(F)F | ||
| 化学名称 | |||
| 分子式 | C18H19F8N5O2 | 分子量 | 489.36 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | Gemigliptin, also known as LC15-0444, is a potent dipeptidyl peptidase-4 (DPP-4) inhibitor was approved in South Korea as an oral anti-hyperglycemic agent (anti-diabetic drug). Gemigliptin dose-dependently inhibited methylglyoxal-modified AGE-bovine serum albumin (BSA) formation (IC50=11.69 mM). AGE-collagen cross-linking assays showed that gemigliptin had a potent inhibitory effect (IC50=1.39 mM) on AGE-BSA cross-links to rat tail tendon collagen, and its activity was stronger than aminoguanidine (IC50=26.4 mM). | ||
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