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SC144 hydrochloride 结构式

SC144 hydrochloride

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货号 ：BCP19383CAS号 ：917497-70-2纯度：98%
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  • 基本信息与产品描述
CAS号 917497-70-2 货号 BCP19383
中文名 SC144 hydrochloride
英文名 SC144 hydrochloride
中文别名
英文别名 SC-144 hydrochloride;SC 144 hydrochloride;
SMILES
化学名称
分子式 C16H12ClFN6O 分子量 358.76
纯度 98% 配送 惯例下常温包邮
产品描述 SC144 shows greater potency in human ovarian cancer cell lines than in normal epithelial cells. SC144 binds gp130, induces gp130 phosphorylation (S782) and deglycosylation, abrogates Stat3 phosphorylation and nuclear translocation, and further inhibits the expression of downstream target genes. In addition, SC144 shows potent inhibition of gp130 ligand-triggered signaling. Oral administration of SC144 delays tumor growth in a mouse xenograft model of human ovarian cancer without significant toxicity to normal tissues.
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