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| CAS号 | 926927-61-9 | 货号 | BCP16667 |
| 中文名 | VTX-2337 | ||
| 英文名 | VTX-2337 | ||
| 中文别名 | |||
| 英文别名 | VTX 2337;VTX2337;Motolimod; | ||
| SMILES | |||
| 化学名称 | |||
| 分子式 | C28H34N4O2 | 分子量 | 458.6 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | VTX-2337 selectively activates TLR8 with an EC(50) of about 100 nmol/L and stimulates production of TNFα and interleukin (IL)-12 from monocytes and myeloid dendritic cells (mDC). VTX-2337 stimulates IFNγ production from NK cells and increases the cytotoxicity of NK cells against K562 and ADCC by rituximab and trastuzumab. Effects of VTX-2337 on NK cells were, in part, from direct activation as increased IFNγ production and cytotoxic activity were seen with purified NK cells. Finally, VTX-2337 augments ADCC by rituximab in PBMCs with different FcγR3A genotypes (V/V, V/F, and F/F at position 158). VTX-2337 is a novel small-molecule TLR8 agonist that activates monocytes, DCs, and NK cells. | ||
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