Pexmetinib 新

参考资料仅供科学研究，不可用于个人用途。

货号：BCP28410CAS号：945614-12-0纯度：98%

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CAS号	945614-12-0	货号	BCP28410
中文名	Pexmetinib
英文名	Pexmetinib
中文别名
英文别名	ARRY614; ARRY-614; ARRY 614;
SMILES	CC1=CC=C(C=C1)N2C(=CC(=N2)C(C)(C)C)NC(=O)NCC3=C(C=CC(=C3)F)OC4=CC5=C(C=C4)N(N=C5)CCO
化学名称
分子式	C31H33FN6O3	分子量	556.63
纯度	98%	配送	惯例下常温包邮
产品描述	Pexmetinib, also known as ARRY-614, is an orally bioavailable small-molecule inhibitor of p38 and Tie2 kinases with potential antineoplastic, anti-inflammatory and antiangiogenic activities. p38/Tie2 kinase inhibitor Arry-614 binds to and inhibits the activities of p38 and Tie2 kinases, which may inhibit the production of proinflammatory cytokines and may decrease tumor angiogenesis and tumor cell growth and survival. p38 is a MAP kinase that is often upregulated in cancer cells, playing a crucial part in the production of a variety of cytokines involved in inflammation and cellular proliferation such as tumor necrosis factor (TNF) and interleukin (IL)-1 and -6. Tie2 is an endothelial cell specific receptor that is activated by angiopoietins, growth factors required for angiogenesis.