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LY2409881 trihydrochloride 结构式

LY2409881 trihydrochloride

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货号 :BCP16149CAS号 :946518-60-1纯度:98%
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  • 基本信息与产品描述
CAS号 946518-60-1 货号 BCP16149
中文名 LY2409881 trihydrochloride
英文名 LY2409881 trihydrochloride
中文别名
英文别名 LY-2409881 trihydrochloride;LY 2409881 trihydrochloride;
SMILES
化学名称
分子式 C24H32Cl4N6OS 分子量 594.43
纯度 98% 配送 惯例下常温包邮
产品描述 in vitro: LY2409881 inhibited constitutively activated NF-κB, and caused concentration- and time-dependent growth inhibition and apoptosis in lymphoma cells. Pretreatment of LY10 with 10 umol/L of LY2409881 prevented the formation of phosphorylated IkB in samples treated with TNFa for 2, 20, and 60 minutes in the presence of abundant IkB protein. in vivo: LY2409881 was safe to mice at three dose levels, 50, 100, and 200 mg/kg, all of which caused significant inhibition of tumor growth. LY2409881 suppressed the activity of the NF-κB subunit p65 in lymphoma cells treated by the HDAC inhibitor romidepsin, underlying a potential mechanism of the marked synergy observed of these two drugs.
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