Adavosertib 新热促

参考资料仅供科学研究，不可用于个人用途。

货号：BCP01928CAS号：955365-80-7纯度：98%

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CAS号	955365-80-7	货号	BCP01928
中文名	Adavosertib
英文名	Adavosertib
中文别名
英文别名	MK1775; MK 1775; AZD1775; AZD-1775; AZD 1775;MK-1775;
SMILES	CC(C)(C1=NC(=CC=C1)N2C3=NC(=NC=C3C(=O)N2CC=C)NC4=CC=C(C=C4)N5CCN(CC5)C)O
化学名称
分子式	C27H32N8O2	分子量	500.6
纯度	98%	配送	惯例下常温包邮
产品描述	Adavosertib is a small molecule inhibitor of the tyrosine kinase WEE1 with potential antineoplastic sensitizing activity. Adavosertib selectively targets and inhibits WEE1, a tyrosine kinase that phosphorylates cyclin-dependent kinase 1 (CDK1, CDC2) to inactivate the CDC2/cyclin B complex. Inhibition of WEE1 activity prevents the phosphorylation of CDC2 and impairs the G2 DNA damage checkpoint. This may lead to apoptosis upon treatment with DNA damaging chemotherapeutic agents. Unlike normal cells, most p53 deficient or mutated human cancers lack the G1 checkpoint as p53 is the key regulator of the G1 checkpoint and these cells rely on the G2 checkpoint for DNA repair to damaged cells. Annulment of the G2 checkpoint may therefore make p53 deficient tumor cells more vulnerable to antineoplastic agents and enhance their cytotoxic effect.

Adavosertib 新 热 促