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CAS号 | Rapalink-1 | 货号 | BCP33282 |
中文名 | Rapalink-1 | ||
英文名 | Rapalink-1 | ||
中文别名 | |||
英文别名 | |||
SMILES | |||
化学名称 | |||
分子式 | C91H138N12O24 | 分子量 | 1784.14 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | RapaLink-1, the third-generation bivalent mTOR inhibitor, combines Rapamycin with MLN0128 (a second-generation mTOR kinase inhibitor) by an inert chemical linker. RapaLink-1 shows better efficacy than Rapamycin or mTOR kinase inhibitors (TORKi), potently blocking cancer-derived, activating mutants of mTOR. RapaLink-1 can cross the blood-brain barrier. RapaLink-1 binding to FKBP12 results in targeted and durable inhibition of mTORC1. Anticancer activity. |
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