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| CAS号 | 1029044-16-3 | 货号 | BCP15183 |
| 中文名 | 培西达替尼 | ||
| 英文名 | Pexidartinib | ||
| 中文别名 | |||
| 英文别名 | PLX 3397;PLX3397;PL-X3397; | ||
| SMILES | FC(C1=CC=C(CNC2=NC=C(CC3=CNC4=NC=C(Cl)C=C43)C=C2)C=N1)(F)F | ||
| 化学名称 | |||
| 分子式 | C20H15ClF3N5 | 分子量 | 417.81 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | Pexidartinib, also know as PLX-3397, is a small-molecule receptor tyrosine kinase (RTK) inhibitor of KIT, CSF1R and FLT3 with potential antineoplastic activity. Multitargeted tyrosine kinase inhibitor PLX3397 binds to and inhibits phosphorylation of stem cell factor receptor (KIT), colony-stimulating factor-1 receptor (CSF1R) and FMS-like tyrosine kinase 3 (FLT3), which may result in the inhibition of tumor cell proliferation and down-modulation of macrophages, osteoclasts and mast cells involved in the osteolytic metastatic disease. FLT3, CSF1R and FLT3 are overexpressed or mutated in many cancer cell types and play major roles in tumor cell proliferation and metastasis. | ||
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