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| CAS号 | 444731-52-6 | 货号 | BCP01839 |
| 关联产品 | 635702-64-6（盐酸帕唑帕尼） | ||
| 中文名 | 帕唑帕尼 | ||
| 英文名 | Pazopanib | ||
| 中文别名 | |||
| 英文别名 | GW 786034;GW-786034;GW786034; | ||
| SMILES | |||
| 化学名称 | |||
| 分子式 | C21H23N7O2S | 分子量 | 437.53 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | Pazopanib potently inhibits VEGF-induced phosphorylation of VEGFR2 in HUVEC cells with IC50 of 8 nM.PPazopanib shows dose-dependent growth inhibition in all synovial sarcoma cell lines including SYO-1 and HS-SY-II cells. Proliferation of SYO-1 and HS-SY-II cells is inhibited even at 1?μg/mL of Pazopanib and is completely abolished at 5?μg/mL. Pazopanib induces G1 arrest, and thereby suppresses the growth of synovial sarcoma cells. Phosphorylation of Akts, GSK-3β, JNKs, p70 S6 Kinase, and mTOR is suppressed in Pazopanib-treated SYO-1 cells compared with that in the vehicle-treated cells. Pazopanib between 20 m g/mL and 22.5 m g/mL shows an increasing reduction of RPE cell viability. | ||
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