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CAS号 | 1125780-41-7 | 货号 | BCP28112 |
中文名 | SKLB610 | ||
英文名 | SKLB610 | ||
中文别名 | |||
英文别名 | SKLB-610; SKLB 610; | ||
SMILES | |||
化学名称 | |||
分子式 | C21H16F3N3O3 | 分子量 | 415.37 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | SKLB610 is a VEGFR inhibitor that potently suppresses human tumor angiogenesis. SKLB610 inhibited angiogenesis-related tyrosine kinase VEGFR2, fibroblast growth factor receptor 2 (FGFR2) and platelet-derived growth factor receptor (PDGFR) at rate of 97%, 65% and 55%, respectively, at concentration of 10μM in biochemical kinase assays. SKLB610 exhibited its antitumor activity as a multi-targeted inhibitor with more potent inhibition of VEGFR2 activity. Its potential to be a candidate of anticancer agent is worth being further investigated. |
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