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PD 161570 结构式

PD 161570

参考资料 仅供科学研究,不可用于个人用途。
货号 :BCP24138CAS号 :192705-80-9纯度:98%
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  • 基本信息与产品描述
CAS号 192705-80-9 货号 BCP24138
中文名 PD 161570
英文名 PD 161570
中文别名
英文别名 PD 161570; PD161570;
SMILES CCN(CC)CCCCNC1=NC2=NC(=C(C=C2C=N1)C3=C(C=CC=C3Cl)Cl)NC(=O)NC(C)(C)C
化学名称
分子式 C26H35Cl2N7O 分子量 532.51
纯度 98% 配送 惯例下常温包邮
产品描述 PD-161570 is a selective FGFR inhibitor (IC50 values are 40, 262 and 3700 nM for FGFR, PDGFR and EGFR respectively). PD 161570 had about 5- and 100-fold greater selectivity toward the FGF-1 receptor (IC50 = 40 nM) compared with the PDGFbeta receptor (IC50 = 262 nM) or EGF receptor (IC50 = 3.7 microM) tyrosine kinases, respectively. In addition, PD 161570 suppressed constitutive phosphorylation of the FGF-1 receptor in both human ovarian carcinoma cells (A121(p)) and Sf9 insect cells overexpressing the human FGF-1 receptor and blocked the growth of A121(p) cells in culture. The results demonstrate a novel synthetic inhibitor with nanomolar potency and specificity towards the FGF-1 receptor tyrosine kinase.
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