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CAS号 | 192705-80-9 | 货号 | BCP24138 |
中文名 | PD 161570 | ||
英文名 | PD 161570 | ||
中文别名 | |||
英文别名 | PD 161570; PD161570; | ||
SMILES | CCN(CC)CCCCNC1=NC2=NC(=C(C=C2C=N1)C3=C(C=CC=C3Cl)Cl)NC(=O)NC(C)(C)C | ||
化学名称 | |||
分子式 | C26H35Cl2N7O | 分子量 | 532.51 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | PD-161570 is a selective FGFR inhibitor (IC50 values are 40, 262 and 3700 nM for FGFR, PDGFR and EGFR respectively). PD 161570 had about 5- and 100-fold greater selectivity toward the FGF-1 receptor (IC50 = 40 nM) compared with the PDGFbeta receptor (IC50 = 262 nM) or EGF receptor (IC50 = 3.7 microM) tyrosine kinases, respectively. In addition, PD 161570 suppressed constitutive phosphorylation of the FGF-1 receptor in both human ovarian carcinoma cells (A121(p)) and Sf9 insect cells overexpressing the human FGF-1 receptor and blocked the growth of A121(p) cells in culture. The results demonstrate a novel synthetic inhibitor with nanomolar potency and specificity towards the FGF-1 receptor tyrosine kinase. |
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