CAY10594 新

参考资料仅供科学研究，不可用于个人用途。

货号：BCP30751CAS号：1130067-34-3纯度：98%

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CAS号	1130067-34-3	货号	BCP30751
中文名	CAY10594
英文名	CAY10594
中文别名
英文别名	CAY 10594;CAY-10594;
SMILES	C1CN(CCC12C(=O)NCN2C3=CC=CC=C3)CCNC(=O)C4=CC5=CC=CC=C5C=C4
化学名称
分子式	C26H28N4O2	分子量	428.53
纯度	98%	配送	惯例下常温包邮
产品描述	CAY10594 is a potent PLD2 inhibitor, both in vitro (IC50 = 140 nM) and in cells (IC50 = 110 nM). It is also effective as a PLD1 inhibitor at higher concentrations (IC50 = 5.1 μM in vitro, 1.0 μM in cells). CAY10594 strongly inhibits the invasive migration of breast cancer cells in transwell assays, suggesting that PLD might be a useful target in blocking tumor cell invasion. Phospholipase D (PLD) is an enzyme which cleaves the head group from phospholipids, producing the second messenger phosphatidic acid. Two mammalian isoforms of PLD, PLD1 and PLD2, have been identified, with multiple splice variants of each. Although the two isoforms share structural and functional features, they are regulated differently and apparently subserve distinct roles.