WYE-125132

参考资料仅供科学研究，不可用于个人用途。

货号：BCP02227CAS号：1144068-46-1纯度：98%

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CAS号	1144068-46-1	货号	BCP02227
中文名	WYE-125132
英文名	WYE-125132
中文别名
英文别名	WYE 125132;WYE125132;
SMILES
化学名称
分子式	C26H31N7O4	分子量	519.61
纯度	98%	配送	惯例下常温包邮
产品描述	WYE-125132 potently and ATP-competitively inhibits recombinant mTOR kinase with IC50 of 0.19 nM and also shows the high selectivity over various PI3Ks and a panel of 230 protein kinases. [1] In vitro, WYE-125132 exhibits a significant anti-proliferative activity against a panel of tumor cell lines with IC50 ranging from 2 nM (LNCap) to 380 nM (HTC116). Besides, WYE-125132 also causes cell cycle progression, induction of apoptosis, and inhibition of protein synthesis and cell size.WYE-125132 results in a significant reduction in the synthesis of pre-tRNALeu by 72%, 80%, and 53% in actively proliferating cells of MG63, MDA361, and HEK293, respectively by inhibiting mTORC1. Moreover, WYE-125132 is also found to induce the dephosphorylation of Maf1 (negative regulator of Pol III transcription) and its accumulation in the nucleus.