度洛西汀

参考资料仅供科学研究，不可用于个人用途。

货号：BCP13463CAS号：116539-59-4纯度：98%

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CAS号	116539-59-4	货号	BCP13463
关联产品	136434-34-9（盐酸度洛西汀） 116817-11-9（(RS)-盐酸度洛西汀） 116539-60-7（R-(-)-度洛西汀）
中文名	度洛西汀
英文名	Duloxetine
中文别名
英文别名	(S)-Duloxetine;LY248686;LY-248686;LY 248686;
SMILES
化学名称
分子式	C18H19NOS	分子量	297.41
纯度	98%	配送	惯例下常温包邮
产品描述	Duloxetine inhibits the reuptake of serotonin and norepinephrine in the central nervous system. Duloxetine is also considered a less potent inhibitor of dopamine reuptake. However, duloxetine has no significant affinity for dopaminergic, adrenergic, cholinergic, histaminergic, opioid, glutamate, and GABA receptors and can therefore be considered to be a selective reuptake inhibitor at the 5-HT and NA transporters. Duloxetine undergoes extensive metabolism, but the major circulating metabolites do not contribute significantly to the pharmacologic activity. Major depressive disorder is believed to be due in part to an increase in pro-inflammatory cytokines within the central nervous system. Antidepressants including ones with a similar mechanism of action as duloxetine, i.e. serotonin metabolism inhibition, cause a decrease in proinflammatory cytokine activity and an increase in anti-inflammatory cytokines; this mechanism may apply to duloxetine in its effect on depression but research o