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Topotecan HCl 结构式

盐酸拓扑替康

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货号 ：BCP00930CAS号 ：119413-54-6纯度：98%
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  • 基本信息与产品描述
CAS号 119413-54-6 货号 BCP00930
中文名 盐酸拓扑替康
英文名 Topotecan HCl
中文别名
英文别名 Hycamtin;Nogitecan hydrochlorid;NSC-609699;NSC 609699;NSC609699;
SMILES
化学名称
分子式 C23H23N3O5.HCl 分子量 457.91
纯度 98% 配送 惯例下常温包邮
产品描述 Stronger drug activity of Topotecan is observed for DU-145 Luc and MCF-7 Luc cells.Topotecan causes cytotoxicity during the course of DNA replication by stabilizing the covalent complex between topoisomerase I and DNA and preventing the religation of enzyme-linked single-strand DNA break. Topotecan stabilizes topoisomerase I/DNA cleavable complexes in radiation-resistant human B-lineage acute lymphoblastic leukemia (ALL) cells, causes rapid apoptotic cell death despite high-level expression of bcl-2 protein, and inhibits ALL cell clonogenic growth in a dose-dependent fashion.
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