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| CAS号 | 1222998-36-8 | 货号 | BCP02504 |
| 中文名 | Torin 1 | ||
| 英文名 | Torin 1 | ||
| 中文别名 | |||
| 英文别名 | Torin1;Torin-1; | ||
| SMILES | |||
| 化学名称 | |||
| 分子式 | C35H28F3N5O2 | 分子量 | 607.64 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | Torin1 inhibits phosphorylation of mTORC1 and mTORC2 substrates in cells at concentrations of 2 and 10 nM, respectively. Moreover, Torin1 exhibits 1000-fold selectivity for mTOR over PI3K (EC50 = 1800 nM) and exhibits 100-fold binding selectivity relative to 450 other protein kinases.Torin1 causes cell cycle arrest through a rapamycin-resistant mechanism that is also independent of mTORC2. Torin1 disrupts mTORC1-dependent phenotypes more completely than rapamycin. Rapamycin-resistant functions of mTORC1 are required for cap-dependent translation.In a recent study, it is reported Torin1 increases neurotensin secretion and gene expression through activation of the MEK/ERK/c-Jun pathway in the human endocrine cell line BON. | ||
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