SR1078

参考资料仅供科学研究，不可用于个人用途。

货号：BCP09203CAS号：1246525-60-9纯度：98%

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CAS号	1246525-60-9	货号	BCP09203
中文名	SR1078
英文名	SR 1078
中文别名
英文别名	SR1078; SR-1078;
SMILES
化学名称
分子式	C17H10F9NO2	分子量	431.25
纯度	98%	配送	惯例下常温包邮
产品描述	SR1078 is a newly described synthetic RORα/γ agonist. Treatment of cancer cells with SR1078 leads to p53 stabilization and induction of apoptosis. SR1078 modulates the conformation of RORγ in a biochemical assay and activates RORα and RORγ driven transcription. Furthermore, SR1078 stimulates expression of endogenous ROR target genes in HepG2 cells that express both RORα and RORγ. Pharmacokinetic studies indicate that SR1078 displays reasonable exposure following injection into mice, and consistent with SR1078 functioning as a RORα/RORγ agonist, expression of two ROR target genes, glucose-6-phosphatase and fibroblast growth factor 21, were stimulated in the liver. Thus, SR1078 can be utilized as a chemical tool to probe the function of these receptors both in vitro and in vivo.