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| CAS号 | 293753-05-6 | 货号 | BCP13177 |
| 中文名 | SR3335 | ||
| 英文名 | SR3335 | ||
| 中文别名 | |||
| 英文别名 | SR-3335;SR 3335; ML 176; ML-176; ML176; | ||
| SMILES | O=S(C1=CC=CS1)(NC2=CC=C(C(C(F)(F)F)(C(F)(F)F)O)C=C2)=O | ||
| 化学名称 | |||
| 分子式 | C13H9F6NO3S2 | 分子量 | 405.34 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | SR3335, also known as ML 176, is a RORα selective inverse agonist. SR3335 directly binds to RORα, but not other RORs, and functions as a selective partial inverse agonist of RORα in cell-based assays. Furthermore, SR3335 suppresses the expression of endogenous RORα target genes in HepG2 involved in hepatic gluconeogenesis including glucose-6-phosphatase and phosphoenolpyruvate carboxykinase. SR3335 can be utilized as a chemical tool to probe the function of this receptor both in vitro and in vivo. SR3335 may hold utility for suppression of elevated hepatic glucose production in type 2 diabetics. | ||
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