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| CAS号 | 1246529-32-7 | 货号 | BCP27897 |
| 中文名 | MPI-0479605 | ||
| 英文名 | MPI-0479605 | ||
| 中文别名 | |||
| 英文别名 | MPI 0479605; MPI0479605; | ||
| SMILES | |||
| 化学名称 | |||
| 分子式 | C22H29N7O | 分子量 | 407.51 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | MPI-0479605 is a potent and selective ATP competitive inhibitor of Mps1. Cells treated with MPI-0479605 undergo aberrant mitosis, resulting in aneuploidy and formation of micronuclei. In cells with wild-type p53, this promotes the induction of a postmitotic checkpoint characterized by the ATM- and RAD3-related-dependent activation of the p53-p21 pathway. In both wild-type and p53 mutant cells lines, there is a growth arrest and inhibition of DNA synthesis. Subsequently, cells undergo mitotic catastrophe and/or an apoptotic response. In xenograft models, MPI-0479605 inhibits tumor growth, suggesting that drugs targeting Mps1 may have utility as novel cancer therapeutics. | ||
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