S1RA hydrochloride

参考资料仅供科学研究，不可用于个人用途。

货号：BCP24076CAS号：1265917-14-3纯度：98%

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CAS号	1265917-14-3	货号	BCP24076
中文名	S1RA hydrochloride
英文名	S1RA hydrochloride
中文别名
英文别名	E52862 HCl;E-52862 hydrochloride;; E-52862 HCl; E 52862 hydrochloride; S1RA hydrochloride;
SMILES	CC1=CC(OCCN2CCOCC2)=NN1C3=CC(C=CC=C4)=C4C=C3.[H]Cl
化学名称
分子式	C20H24ClN3O2	分子量	373.88
纯度	98%	配送	惯例下常温包邮
产品描述	S1RA Hcl(E-52862 Hcl) is a potent and selective sigma-1 receptor(σ1R, Ki=17 nM) antagonist, showed good selectivity against σ2R (Ki > 1000 nM).E-52862, also known as S1RA, is a selective sigma-1 receptor antagonist, with a reported binding affinity of Ki = 17.0 ± 7.0 nM, selective over the sigma-2 receptor and against a panel of other 170 receptors, enzymes, transporters and ion channels. In preclinical studies, S1RA has demonstrated efficacy in relieving neuropathic pain and pain in other sensitizing conditions, associated with an improvement of the emotional negative state. E-52862 attenuates neuropathic pain of different aetiology in rats.