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  >   ENMD-2076 酒石酸盐
ENMD-2076 Tartrate 结构式

ENMD-2076 酒石酸盐

参考资料 仅供科学研究,不可用于个人用途。
货号 :BCP14868CAS号 :1291074-87-7纯度:98%
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  • 基本信息与产品描述
CAS号 1291074-87-7 货号 BCP14868
中文名 ENMD-2076 酒石酸盐
英文名 ENMD-2076 Tartrate
中文别名
英文别名 ENMD2076; ENMD 2076; ENMD-2076;
SMILES CC1=CC(=NN1)NC2=NC(=NC(=C2)N3CCN(CC3)C)C=CC4=CC=CC=C4.C(C(C(=O)O)O)(C(=O)O)O
化学名称
分子式 C25H31N7O6 分子量 525.56
纯度 98% 配送 惯例下常温包邮
产品描述 ENMD-2076 Tartrate is a multi-targeted kinase inhibitor with IC50s of 1.86, 14, 58.2, 15.9, 92.7, 70.8, 56.4 nM for Aurora A, Flt3, KDR/VEGFR2, Flt4/VEGFR3, FGFR1, FGFR2, Src, PDGFRα, respectively.ENMD-2076 is an orally-active, Aurora A/angiogenic kinase inhibitor with a unique kinase selectivity profile and multiple mechanisms of action. ENMD-2076 has been shown to inhibit a distinct profile of angiogenic tyrosine kinase targets in addition to the Aurora A kinase. Aurora kinases are key regulators of mitosis (cell division), and are often over-expressed in human cancers. ENMD-2076 also targets the VEGFR, Flt-3 and FGFR3 kinases which have been shown to play important roles in the pathology of several cancers.
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