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XL-228 结构式

XL-228

参考资料 仅供科学研究，不可用于个人用途。
货号 ：BCP08143CAS号 ：898280-07-4纯度：98%
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  • 基本信息与产品描述
CAS号 898280-07-4 货号 BCP08143
中文名 XL-228
英文名 XL-228
中文别名
英文别名 XL228;XL 228;
SMILES
化学名称
分子式 C22H31N9O 分子量 437.54
纯度 98% 配送 惯例下常温包邮
产品描述 Approximately 30% of the lines demonstrated XL228 IC50 values of <100nM in viability assays, including many lines with characterized ALK or FGFR mutations or amplifications. Cell lines showing the highest level of response to XL228 were often sensitive to other Aurora, ALK or FGFR inhibitors as well. Sub-20nM activity was demonstrated against FGFR2 in a cellular kinase ELISA assay, and confirmed by immunoblot analysis. Potency against ALK in the cell kinase assay was lower (approximately200 nM)
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