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CAS号 | 1370261-96-3 | 货号 | BCP06469 |
中文名 | PRT062607 | ||
英文名 | PRT062607 | ||
中文别名 | |||
英文别名 | P5 0515;P50515;PRT-062607;PRT 062607;PRT062607; | ||
SMILES | |||
化学名称 | |||
分子式 | C19H23N9O | 分子量 | 393.45 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | PRT062607(P505-15) anti-SYK activity is at least 80-fold greater than its affinity for other kinases. at least 80-fold greater than its affinity for other kinases. PRT062607 potently inhibits B cell antigen receptor-mediated B cell signaling and activation (IC50 0.27 and 0.28 μM, respectively) and Fcε receptor 1-mediated basophil degranulation (IC50 0.15 μM).PRT062607 inhibits BCR-dependent secretion of the chemokines CCL3 and CCL4 by CLL cells, and leukemia cell migration toward the tissue homing chemokines CXCL12, CXCL13, and beneath stromal cells. PRT062607 furthermore inhibits Syk and extracellular signal-regulated kinase phosphorylation after BCR triggering. |
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