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PRT062607 结构式

PRT062607

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货号 :BCP06469CAS号 :1370261-96-3纯度:98%
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  • 基本信息与产品描述
CAS号 1370261-96-3 货号 BCP06469
中文名 PRT062607
英文名 PRT062607
中文别名
英文别名 P5 0515;P50515;PRT-062607;PRT 062607;PRT062607;
SMILES
化学名称
分子式 C19H23N9O 分子量 393.45
纯度 98% 配送 惯例下常温包邮
产品描述 PRT062607(P505-15) anti-SYK activity is at least 80-fold greater than its affinity for other kinases. at least 80-fold greater than its affinity for other kinases. PRT062607 potently inhibits B cell antigen receptor-mediated B cell signaling and activation (IC50 0.27 and 0.28 μM, respectively) and Fcε receptor 1-mediated basophil degranulation (IC50 0.15 μM).PRT062607 inhibits BCR-dependent secretion of the chemokines CCL3 and CCL4 by CLL cells, and leukemia cell migration toward the tissue homing chemokines CXCL12, CXCL13, and beneath stromal cells. PRT062607 furthermore inhibits Syk and extracellular signal-regulated kinase phosphorylation after BCR triggering.
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