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CAS号 | 1393477-72-9 | 货号 | BCP08966 |
中文名 | 塞利尼索 | ||
英文名 | Selinexor | ||
中文别名 | |||
英文别名 | 1421923-86-5(E-isomer) ;KPT-330;KPT 330;KPT330; Xpovio; | ||
SMILES | C1=CN=C(C=N1)NNC(=O)C=CN2C=NC(=N2)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F | ||
化学名称 | |||
分子式 | C17H11F6N7O | 分子量 | 443.31 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | KPT-330 dramatically suppresses the growth of T-ALL cells (MOLT-4) and AML cells (MV4–11) in vivo, with little toxicity to normal haematopoietic cells. In SCID mice with diffuse human MM bone lesions, KPT-330 inhibits MM-induced bone lysis and prolongs survival. Moreover, KPT-330 directly impairs osteoclastogenesis and bone resorption by blocking RANKL-induced NF-κB and NFATc1, with minimal impact on osteoblasts and BMSCs. |
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