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GS-4997 HCl salt 结构式

GS-4997 HCl salt

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货号 :BCP20629CAS号 :1448428-05-4纯度:98%
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  • 基本信息与产品描述
CAS号 1448428-05-4 货号 BCP20629
中文名 GS-4997 HCl salt
英文名 GS-4997 HCl salt
中文别名
英文别名 GS-4997; GS4997; GS 4997; Selonsertib;
SMILES
化学名称
分子式 C24H25ClFN7O 分子量 481.96
纯度 98% 配送 惯例下常温包邮
产品描述 Selonsertib, also known as GS-4997, is an orally bioavailable inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with potential anti-inflammatory, antineoplastic and anti-fibrotic activities. GS-4997 targets and binds to the catalytic kinase domain of ASK1 in an ATP-competitive manner, thereby preventing its phosphorylation and activation. GS-4997 prevents the production of inflammatory cytokines, down-regulates the expression of genes involved in fibrosis, suppresses excessive apoptosis and inhibits cellular proliferation.
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