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NMS-859 结构式

NMS-859

参考资料 仅供科学研究，不可用于个人用途。
货号 ：BCP19908CAS号 ：1449236-96-7纯度：98%
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  • 基本信息与产品描述
CAS号 1449236-96-7 货号 BCP19908
中文名 NMS-859
英文名 NMS-859
中文别名
英文别名 NMS859;NMS 859;
SMILES
化学名称
分子式 C15H12ClN3O3S 分子量 349.79
纯度 98% 配送 惯例下常温包邮
产品描述 NMS-859 is very selective (IC50 >10 μM) against all of the AAA ATPases, HSP90 or the 53 kinases tested. NMS-859 was active in a cell proliferation assay, with IC50 values of 3.5 μM and 3.0 μM in HCT116 and HeLa cell lines, respectively. NMS-859 covalently modifies VCP on the active site Cys522 and blocks ATP binding. NMS-859 provided critical validation of VCP as a cancer target, and it raises the possibility that targeting VCP might prevent proteasome inhibitor–resistant tumors from escaping through the aggresome-autophagy pathways and cause them to collapse under the high load of unfolded proteins.
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