BMS-986115 新

参考资料仅供科学研究，不可用于个人用途。

货号：BCP49196CAS号：1584647-27-7纯度：98%

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CAS号	1584647-27-7	货号	BCP49196
中文名	BMS-986115
英文名	BMS-986115
中文别名
英文别名	Notch inhibitor 1; BMS 986115; BMS986115;AL-102;AL 102;AL102;
SMILES	CC1=C2C(=CC=C1)C(=NC(C(=O)N2)NC(=O)C(CCC(F)(F)F)C(CCC(F)(F)F)C(=O)N)C3=CC(=CC=C3)F
化学名称
分子式	C26H25F7N4O3	分子量	574.49
纯度	98%	配送	惯例下常温包邮
产品描述	BMS-986115 is an orally bioavailable, gamma secretase (GS) and pan-Notch inhibitor, with potential antineoplastic activity. Upon administration, GS/pan-Notch inhibitor BMS 986115 binds to GS and blocks the proteolytic cleavage and release of the Notch intracellular domain (NICD), which would normally follow ligand binding to the extracellular domain of the Notch receptor. This prevents both the subsequent translocation of NICD to the nucleus to form a transcription factor complex and the expression of Notch-regulated genes. This results in the induction of apoptosis and the inhibition of growth of tumor cells that overexpress Notch. Overexpression of the Notch signaling pathway plays an important role in tumor cell proliferation and survival.