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| CAS号 | 1627503-67-6 | 货号 | BCP12392 |
| 中文名 | LDN-214117 | ||
| 英文名 | LDN-214117 | ||
| 中文别名 | |||
| 英文别名 | LDN214117;LDN 214117; | ||
| SMILES | |||
| 化学名称 | |||
| 分子式 | C25H29N3O3 | 分子量 | 419.52 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | LDN-214117 inhibited ALK2 most, with a biochemical IC50 of 24 nM, followed by TNIK, RIPK2, and ABL1. LDN-214117 has a cell-based IC50 for BMP6 of approximately 100 nM and 164-fold selectivity for BMP6 versus TGF-β1. Fibrodysplasia ossificans progressiva (FOP) is a debilitating and progressive heterotopic ossification disease caused by activating mutations of ACVR1 encoding the BMP type I receptor kinase ALK2. LDN-214117 had nearly identical binding affinity for wild-type ALK2 and each of the FOP-causing mutants tested. | ||
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