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GS-9901

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货号 :BCP44115CAS号 :1640247-87-5纯度:98%
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  • 基本信息与产品描述
CAS号 1640247-87-5 货号 BCP44115
中文名 GS-9901
英文名 GS-9901
中文别名
英文别名 GS 9901; GS9901;
SMILES C1CC1C(C2=NC3=C(C=CC(=C3C(=O)N2C4=CN=CC=C4)Cl)F)NC5=NC(=NC(=C5C#N)N)N
化学名称
分子式 C22H17ClFN9O 分子量 477.89
纯度 98% 配送 惯例下常温包邮
产品描述 GS-9901 is a potent, orally active and highly selective inhibitor of PI3Kδ (PI3Kdelta IC50 = 1.0nM, HWB delta EC50 = 1.5 nM; CLpr hHep = 0.05 L/h/kg.). GS-9901 displays an excellent pharmacokinetic profile and is efficacious in a rodent model of rheumatoid arthritis. GS-9901 demonstrates efficacy in a rat model of arthritis and is predicted to be suitable for q.d. dosing in humans. The favorable in vitro and in vivo attributes of GS-9901 resulted in its selection as a development candidate.
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