Padnarsertib 新

参考资料仅供科学研究，不可用于个人用途。

货号：BCP10637CAS号：1643913-93-2纯度：98%

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CAS号	1643913-93-2	货号	BCP10637
中文名	Padnarsertib
英文名	Padnarsertib
中文别名
英文别名	KPT9274;PAK4-IN-1;KPT-9274;KPT 9274; PAK4-IN-1; PAK4-IN 1; PAK4-IN1;
SMILES	C1CN(CCC1(F)F)C(=O)C2=CC=C(C=C2)C3=CC(=C4C(=C3)C=C(O4)CNC(=O)C=CC5=CN=C(C=C5)N)C6=CC=C(C=C6)F
化学名称
分子式	C35H29F3N4O3	分子量	610.63
纯度	98%	配送	惯例下常温包邮
产品描述	Padnarsertib is a potent, selective and dual PAK4/NAMPT inhibitor. KPT-9274 interferences with PAK4/NAMPT signaling pathways, which results in reduction of G2-M transit as well as induction of apoptosis and decrease in cell invasion and migration in several human RCC cell lines. Mechanistic studies demonstrate that inhibition of the PAK4 pathway by KPT-9274 attenuates nuclear β-catenin as well as the Wnt/β-catenin targets cyclin D1 and c-Myc. KPT-9274 demonstrated the expected on-target effects in this mouse model. KPT-9274 is being evaluated in a phase I human clinical trial in solid tumors and lymphomas, which will allow this data to be rapidly translated into the clinic for the treatment of RCC.