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| CAS号 | 162359-56-0 | 货号 | BCP01808 |
| 中文名 | 盐酸芬戈莫德 | ||
| 英文名 | Fingolimod HCl | ||
| 中文别名 | |||
| 英文别名 | Fingolimod;Gilenia;FTY720; FTY-720; FTY 720;Fingolimod hydrochloride; | ||
| SMILES | |||
| 化学名称 | |||
| 分子式 | C19H33NO2.HCl | 分子量 | 343.93 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | The inhibitory effect of S1P is revered by various concentrations of FTY720, with IC50 effect of 173 nM. In addition, FTY720 (10 nM) alone exerts no effect on the expression of co-stimulatory molecules. FTY720 reverses the increased expression of HLA-I induced by S1P for both the percentages of cells and the MFI, upon comparing the effect of S1P to the effect of combining S1P with FTY720.Medium and high-dose FTY720-P also enhances the levels of TGF-β1. TGF-β1 and Foxp3 mRNA expression are upregulated in the high-dose FTY720-P group. The proliferation of effector T cells is suppressed significantly in the medium and high-dose FTY720-P group at a Treg/Teff cell ratio of 1:1. At a ratio of 1:1, the proliferation of effector T cells is also suppressed in the high-dose FTY720 group. | ||
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