PMPA

参考资料仅供科学研究，不可用于个人用途。

货号：BCP08861CAS号：173039-10-6纯度：98%

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CAS号	173039-10-6	货号	BCP08861
中文名	PMPA
英文名	PMPA
中文别名
英文别名	NAALADaseinhibitor；2-PMPA；2-(Phosphonomethyl)pentanedioic acid;
SMILES
化学名称
分子式	C6H11O7P	分子量	226.12
纯度	98%	配送	惯例下常温包邮
产品描述	PMPA is a NAALADase inhibitor. PMPA increases threshold for electroconvulsions and enhances the antiseizure action of valproate against maximal electroshock-induced seizures in mice. Inhibition of NAALADase by 2-PMPA attenuates cocaine-induced relapse in rats: a NAAG-mGluR2/3-mediated mechanism. PMPA attenuates magnetic resonance BOLD signals in brain of anesthetized mice: evidence of a link between neuron NAAG release and hyperemia.Highly potent and selective inhibitor of glutamate carboxypeptidase 2 (GCP II/N-acetylated α-linked dipeptidase/NAALADase) with a Ki value of 275 pM. Neuroprotective; protects against glutamate-mediated motor neuron degeneration and reduces volume of injury following middle cerebral artery occlusion (MCAO).