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| CAS号 | 198821-22-6 | 货号 | BCP28336 |
| 中文名 | MeriMepodib | ||
| 英文名 | MeriMepodib | ||
| 中文别名 | |||
| 英文别名 | VX497; VX-497; VX 497; MMP; VI21497; VI-21497; VI 21497; | ||
| SMILES | |||
| 化学名称 | |||
| 分子式 | C23H24N4O6 | 分子量 | 452.46 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | Merimepodib, also known as VX-497, is orally bioavailable IMPDH inhibitor, which inhibits the proliferation of primary human, mouse, rat, and dog lymphocytes at concentrations of approximately 100 nM. In vivo, oral administration of VX-497 inhibits the primary IgM antibody response in a dose-dependent manner, with an ED(50) value of approximately 30-35 mg/kg in mice. Single daily dosing of VX-497 is observed to be as effective as twice-daily dosing in this model of immune activation. These studies demonstrate that VX-497 is a potent, specific, and reversible IMPDH inhibitor that selectively inhibits lymphocyte proliferation. | ||
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