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| CAS号 | 2055597-39-0 | 货号 | BCP48484 |
| 关联产品 | 2055597-12-9（ASN007） | ||
| 中文名 | ASN007 benzenesulfonate | ||
| 英文名 | ASN007 benzenesulfonate | ||
| 中文别名 | |||
| 英文别名 | ASN-007 benzenesulfonate ;ASN 007 benzenesulfonate ;ERK-IN-3 benzenesulfonate; | ||
| SMILES | |||
| 化学名称 | |||
| 分子式 | C28H31ClFN7O5S | 分子量 | 632.11 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | ASN007, a novel oral ERK inhibitor, shows robust antitumor activity in RAS mutant cancer models. with low single-digit nM IC50 values. ASN007 showed a slow dissociation rate (long target residence time) as compared to several other known ERK inhibitors. In mechanistic cell-based assays, ASN007 inhibited the phosphorylation of ERK1/2 substrates such as RSK1, FRA1, and Elk1 in various cell lines. ASN007 showed single-digit nanomolar antiproliferative activity that was selective for MAPK-pathway dependent cancer cell lines. | ||
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