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CAS号 | 218600-53-4 | 货号 | BCP04660 |
中文名 | 甲基巴多索隆 | ||
英文名 | Bardoxolone methyl | ||
中文别名 | |||
英文别名 | CDDO Methyl ester; CDDOMe; NSC 713200; RTA 402; RTA-402; RTA402; TP-155; TP155; TP 155; | ||
SMILES | O=C([C@]1(CC[C@@]2(C)[C@]3(C)CCC4C(C)(C)C(C(C#N)=C[C@]4(C)C3=C5)=O)CCC(C)(C)C[C@]1([H])[C@@]2([H])C5=O)OC | ||
化学名称 | |||
分子式 | C32H43NO4 | 分子量 | 505.69 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | Bardoxolone methyl (also known as “RTA 402” and “CDDO-methyl ester”) is an orally-available first-in-class synthetic triterpenoid belonging to the antioxidant inflammation modulator (AIM) class. It is the most potent known inducer of the Nrf2 pathway to enter clinical development and works to suppress both oxidative stress and inflammation. Bardoxolone methyl is currently being developed by Reata Pharmaceuticals, Inc. in partnership with Abbott Laboratories and Kyowa Hakko Kirin, for the treatment of advanced chronic kidney disease (CKD) in type 2 diabetes mellitus patients. |
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