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| CAS号 | 2271119-26-5 | 货号 | BCP40929 |
| 中文名 | Elzovantinib | ||
| 英文名 | Elzovantinib | ||
| 中文别名 | |||
| 英文别名 | TPX-0022; TPX 0022; TPX0022;CSF1R-IN-2; | ||
| SMILES | CCN1CC2=C(C=CC(=C2C#N)F)OC(CNC(=O)C3=C4N=C1C=CN4N=C3N)C | ||
| 化学名称 | |||
| 分子式 | C20H20FN7O2 | 分子量 | 409.42 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | TPX-0022, also known as CSF1R-IN-2, is an orally bioavailable multi-targeted kinase inhibitor with a novel three-dimensional macrocyclic structure that inhibits the MET, CSF1R (colony stimulating factor 1 receptor) and SRC kinases. Targeting CSF1R leads to the modulation of tumor-associated macrophages (TAMs), a type of immune cell that suppresses the T-cell mediated anti-tumor immune response. Inhibition of CSF1R with TPX-0022 is a promising therapeutic strategy as a single agent or in combination with standard of care chemotherapy and immunotherapy in various solid tumors. | ||
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