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CAS号 | 2375420-34-9 | 货号 | BCP35922 |
中文名 | SR-717 free acid | ||
英文名 | SR-717 free acid | ||
中文别名 | |||
英文别名 | SR 717; SR717; | ||
SMILES | O=C(C1=CC(F)=C(C=C1NC(C2=NN=C(C=C2)N3C=CN=C3)=O)F)O | ||
化学名称 | |||
分子式 | C15H9F2N5O3 | 分子量 | 345.26 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | SR-717 is an agonist of stimulator of interferon genes STING for treating cancer. SR-717 demonstrates broad interspecies and interallelic specificity. SR-717 functions as a direct cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) mimetic that induces the same "closed" conformation of STING. SR-717 displayed antitumor activity; promoted the activation of CD8+ T, natural killer, and dendritic cells in relevant tissues; and facilitated antigen cross-priming. SR-717 also induced the expression of clinically relevant targets, including programmed cell death 1 ligand 1 (PD-L1), in a STING-dependent manner. |
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