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CAS号 | 288150-92-5 | 货号 | BCP02343 |
中文名 | SB408124 | ||
英文名 | SB408124 | ||
中文别名 | |||
英文别名 | SB-408124;SB 408124; | ||
SMILES | |||
化学名称 | |||
分子式 | C19H18F2N4O | 分子量 | 356.38 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | SB-408124 binds hypocretin type 1 receptor (HcrtR1) with pKi values of 7.57. Calcium mobilization studies shows that SB-408124 is a functional antagonist of the OX1 receptor with a affinity of approximately 50-fold selectivity over the OX2 receptor. A recent study indicates that pretreatment of primary cultures of rat astrocytes with SB-401824 before Orexin A administration significantly reduced the stimulatory action of Orexin A on both basal and forskolin-acivated cAMP production. |
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