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CAS号 | 329198-87-0 | 货号 | BCP31292 |
中文名 | C-178 | ||
英文名 | C-178 | ||
中文别名 | |||
英文别名 | C 178;C178;STING inhibitor C-178; | ||
SMILES | C1=CC=C2C(=C1)C3=C(O2)C=C(C=C3)NC(=O)C4=CC=C(O4)[N+](=O)[O-] | ||
化学名称 | |||
分子式 | C17H10N2O5 | 分子量 | 322.27 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | C-178, a covalent inhibitor of STING, binds to Cys91, potently and selectively suppresses the STING responses elicited by distinct bona fide activators in mouse but not human. C-178 significantly reduces STING-, but not RIG-I- or TBK1-, mediated IFN-β reporter activity. C-178 blocks palmitoylation (PMA)-induced clustering of STING; inhibits the CMA-induced phosphorylation of TBK1 (downstream protein kinase of STING). |
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