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CAS号 | 371935-74-9 | 货号 | BCP01923 |
关联产品 | 371935-79-4(PI-103 Hydrochloride) PI-103(PI-103氢溴酸盐) | ||
中文名 | PI-103 | ||
英文名 | PI-103 | ||
中文别名 | |||
英文别名 | PI 103;PI103; | ||
SMILES | |||
化学名称 | |||
分子式 | C19H16N4O3 | 分子量 | 348.36 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | PI-103 potently inhibits both the rapamycin-sensitive (mTORC1) and rapamycin-insensitive (mTORC2) complexes of the protein kinase mTOR. PI-103 inhibits constitutive and growth factor-induced PI3K/Akt, as well as mTORC1 activation. In blast cells, PI-103 inhibits leukemic proliferation, the clonogenicity of leukemic progenitors and induces mitochondrial apoptosis, especially in the compartment containing leukemic stem cells. PI-103 inhibits p110α >200-fold more potently than p110β. PI-103 also potently blocks production of PI(3,4)P2 and PIP3 in adipocytes and PIP3 in myotubes.PI-103 inhibits phosphorylation of Akt with an IC95 100-fold lower than that for LY294002. Strikingly, PI-103 completely protects animals from insulin-stimulated decline in blood glucose. PI-103 has additive proapoptotic effects with etoposide in blast cells and in immature leukemic cells. |
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