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PI-103 结构式

PI-103

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货号 :BCP01923CAS号 :371935-74-9纯度:98%
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  • 瀚香生物(Biochempartner)的PI-103被文献引用
  • 基本信息与产品描述
CAS号 371935-74-9 货号 BCP01923
关联产品 371935-79-4(PI-103 Hydrochloride) PI-103(PI-103氢溴酸盐)
中文名 PI-103
英文名 PI-103
中文别名
英文别名 PI 103;PI103;
SMILES
化学名称
分子式 C19H16N4O3 分子量 348.36
纯度 98% 配送 惯例下常温包邮
产品描述 PI-103 potently inhibits both the rapamycin-sensitive (mTORC1) and rapamycin-insensitive (mTORC2) complexes of the protein kinase mTOR. PI-103 inhibits constitutive and growth factor-induced PI3K/Akt, as well as mTORC1 activation. In blast cells, PI-103 inhibits leukemic proliferation, the clonogenicity of leukemic progenitors and induces mitochondrial apoptosis, especially in the compartment containing leukemic stem cells. PI-103 inhibits p110α >200-fold more potently than p110β. PI-103 also potently blocks production of PI(3,4)P2 and PIP3 in adipocytes and PIP3 in myotubes.PI-103 inhibits phosphorylation of Akt with an IC95 100-fold lower than that for LY294002. Strikingly, PI-103 completely protects animals from insulin-stimulated decline in blood glucose. PI-103 has additive proapoptotic effects with etoposide in blast cells and in immature leukemic cells.
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