盐酸帕唑帕尼

参考资料仅供科学研究，不可用于个人用途。

货号：BCP02203CAS号：635702-64-6纯度：98%

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CAS号	635702-64-6	货号	BCP02203
关联产品	444731-52-6（帕唑帕尼）
中文名	盐酸帕唑帕尼
英文名	Pazopanib HCl
中文别名
英文别名	Pazopanib hydrochloride;GW786034 HCl;GW-786034 HCl;GW 786034 HCl;
SMILES
化学名称
分子式	C21H23N7O2S.HCl	分子量	473.98
纯度	98%	配送	惯例下常温包邮
产品描述	Pazopanib potently inhibits VEGF-induced phosphorylation of VEGFR2 in HUVEC cells with IC50 of 8 nM.PPazopanib shows dose-dependent growth inhibition in all synovial sarcoma cell lines including SYO-1 and HS-SY-II cells. Proliferation of SYO-1 and HS-SY-II cells is inhibited even at 1?μg/mL of Pazopanib and is completely abolished at 5?μg/mL. Pazopanib induces G1 arrest, and thereby suppresses the growth of synovial sarcoma cells. Phosphorylation of Akts, GSK-3β, JNKs, p70 S6 Kinase, and mTOR is suppressed in Pazopanib-treated SYO-1 cells compared with that in the vehicle-treated cells.Pazopanib between 20 m g/mL and 22.5 m g/mL shows an increasing reduction of RPE cell viability.