GW-6604 新

参考资料仅供科学研究，不可用于个人用途。

货号：BCP13570CAS号：452342-37-9纯度：98%

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CAS号	452342-37-9	货号	BCP13570
中文名	GW-6604
英文名	GW-6604
中文别名
英文别名	GW6604;GW 6604;
SMILES	C1=CC=C(C=C1)C2=NC=CC(=C2)C3=C(NN=C3)C4=CC=CC=N4
化学名称
分子式	C19H14N4	分子量	298.35
纯度	98%	配送	惯例下常温包邮
产品描述	GW6604 is a potent and selective ALK-5 inhibitor with potent anticancer activity. GW6604 is also a TGF-beta signaling pathway inhibitor. In vitro, GW6604 inhibited autophosphorylation of ALK5 with an IC(50) of 140 nM and in a cellular assay inhibited TGF-beta-induced transcription of PAI-1 (IC(50): 500 nM). In vivo, GW6604 (40 mg kg(-1) p.o.) increased liver regeneration in TGF-beta-overexpressing mice, which had undergone partial hepatectomy. In an acute model of liver disease, GW6604 reduced by 80% the expression of collagen IA1. Inhibition of ALK5 could be an attractive new approach to treatment of liver fibrotic diseases by both preventing matrix deposition and promoting hepatocyte regeneration.