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CAS号 | 879487-87-3 | 货号 | BCP25191 |
中文名 | R-268712 | ||
英文名 | R-268712 | ||
中文别名 | |||
英文别名 | R 268712; R268712; | ||
SMILES | CC1=NC(=CC=C1)C2=C(C=NN2)C3=CC(=C(C=C3)F)C4=CN(N=C4)CCO | ||
化学名称 | |||
分子式 | C20H18FN5O | 分子量 | 363.39 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | R-268712 is an orally active and selective ALK-5 inhibitor, with an IC50 of 2.5 nM. R-268712 inhibits the phosphorylation of Smad3 in a dose-dependent manner with an IC50 of 10.4 nM. R-268712 suppresses glomerulonephritis as well as glomerulosclerosis by inhibiting TGF-β signaling, which can be used in studies of renal fibrosis and cancer. |
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