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CAS号 | 60-81-1 | 货号 | BCP29914 |
中文名 | Phlorizin | ||
英文名 | Phlorizin | ||
中文别名 | |||
英文别名 | Phloridzin; phloretin-2'-β-D-glucopyranoside; AI3-19835; NSC 2833; Phloretin 2'-glucoside; Phloretin-2'-O-beta-glucoside; Phlorizoside; Phlorrhizin; | ||
SMILES | C1=CC(=CC=C1CCC(=O)C2=C(C=C(C=C2OC3C(C(C(C(O3)CO)O)O)O)O)O)O | ||
化学名称 | |||
分子式 | C21H24O10 | 分子量 | 436.41 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | Phlorizin, also referred to as phloridzin, is a glucoside of phloretin, a dihydrochalcone, a family of bicyclic flavonoids, which in turn is a subgroup in the diverse phenylpropanoid synthesis pathway in plants. Phlorizin is a competitive inhibitor of SGLT1 and SGLT2 because it competes with D-glucose for binding to the carrier; this reduces renal glucose transport, lowering the amount of glucose in the blood. Phlorizin was studied as a potential pharmaceutical treatment for type 2 diabetes, but has since been superseded by more selective and more promising synthetic analogs, such as canagliflozin and dapagliflozin. |
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