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| CAS号 | 67469-69-6 | 货号 | BCP21322 |
| 中文名 | Vanoxerine | ||
| 英文名 | Vanoxerine | ||
| 中文别名 | |||
| 英文别名 | GBR-12909; GBR12909; GBR 12909; I-893; I 893; I893; | ||
| SMILES | C1CN(CCN1CCCC2=CC=CC=C2)CCOC(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F | ||
| 化学名称 | |||
| 分子式 | C28H32F2N2O | 分子量 | 450.56 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | Vanoxerine (GBR-12909, I-893, Boxeprazine) is a highly potent inhibitor of dopamine uptake in vitro in tissue slices obtained from rat neostriatum with IC50 of 40-50 nM, also inhibits norepinephrine uptake with IC50 of 560-2600 nM; Vanoxerine also is a potent hK(v)11.1 blocker, and at submicromolar concentrations, it blocks Ca and Na currents in a strongly frequency-dependent manner possesses anticonvulsant activity in zebrafish and rodent models of generalized epilepsy but with cardiac ion channel effects. | ||
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